Daniel Fazakerley, PhD, Group Leader
Dr Fazakerley studied for his PhD with Professor Geoff Holman at the University at Bath from 2006 to 2010. During this time he investigated the intracellular trafficking of the glucose transporter, GLUT4, in skeletal muscle. Following award of his PhD in 2010, Dr Fazakerley joined Professor James’ group, then at the Garvan Institute in Sydney, on a Sir Henry Wellcome Fellowship from the Wellcome Trust. He moved to his current position at the CPC in 2014. He currently leads the Mechanisms of Insulin Resistance group as part of Professor David James' lab.
Dr Fazakerley investigates how cells and tissues respond to insulin and how these responses become defective in metabolic disease, specifically in pre-diabetes or insulin resistance. While we have known for a long time that impaired insulin-stimulated glucose transport in muscle and fat is a major cause of insulin resistance there is no consensus on the molecular basis for impaired insulin responses. Using proteomic techniques he has revealed a range of cellular pathways that are perturbed in insulin resistance and that appear to impinge on insulin action. His major focus is understanding how these proteins and pathways regulate insulin action and whether they can be targeted to overcome insulin resistance.