Kinase regulated signal transduction

Exercise is arguably one of the most beneficial actions for your body. We hypothesise this is mediated by a complex array of phosphorylation based signal transduction mechanisms. We are using a range of techniques to unravel this complexity in a variety of models. A complete understanding of these processes will translate into improved human health for many diseases.






Figure 1. Phosphoproteomics of exercise models and validation of new signalling substrates regulating important cellular processes associated with exercise









Figure 2. Phosphorylated substrates in response to exercise and their upstream kinases

Training adaptations

Repeated bouts of exercise remodel cellular processes to adapt to changing demands. These adaptations are vital and this fascinating area is uncovering unexplored ways of dealing with stress. We are combining various models of exercise training and systems biology to discover how and when these adaptations occur.


Figure 3.   Exercise training improves insulin sensitivity

Figure 3. Exercise training improves insulin sensitivity

Exercise mimetics

Exercise therapy is being used to treat a range of diseases including cancer, diabetes and mood disorders. However for many people efficient exercise is not an option. Many current therapeutics to treat diseases such as diabetes are essentially exercise mimetics. We propose many more therapeutic targets that are associated with exercise remain to be discovered. We are working with a variety of drug companies to help develop new exercise mimetics focused on phosphorylation signalling.






Figure 4. New drugs can mimic the phosphorylation changes observed with exercise.