Guang Yang, PhD
I received my Ph.D. in Biochemistry and Molecular Biology at Shanghai Institute for Biological Sciences (SIBS), Chinese Academy of Sciences. During my Ph.D., I discovered a novel role of tyrosine protein-kinase Csk in tight junction formation through MS-based interactome analysis and found that CASK, a multidomain scaffolding protein, plays an important role in the regulation of glucose uptake and insulin secretion.
In September 2010, I joined in James Lab as a postdoctoral research fellow. I am mainly interested in the molecular mechanism of mTOR signalling regulation and its role in cell metabolism and longevity. By using cell biology and MS-based phosphproteomic approaches, I revealed Akt enhances mTORC2 activity through phosphorylating SIN1, a key component of mTORC2. I am also working on building the protein-protein network of insulin signalling through ananlysing the interactome of key molecules in the pathway.