2017

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism. Krycer JR, Yugi K, Hirayama A, Fazakerley DJ, Quek LE, Scalzo R, Ohno S, Hodson MP, Ikeda S, Shoji F, Suzuki K, Domanova W, Parker BL, Nelson ME, Humphrey SJ, Turner N, Hoehn KL, Cooney GJ, Soga T, Kuroda S, James DE. Cell Rep. 2017 Dec 19;21(12):3536-3547. doi: 10.1016/j.celrep.2017.11.085.

Glucose Transport: Methods for Interrogating GLUT4 Trafficking in Adipocytes. Norris DM, Geddes TA, James DE, Fazakerley DJ, Burchfield JG. Methods Mol Biol. 2018;1713:193-215. doi: 10.1007/978-1-4939-7507-5_15.

Metabolomic analysis of insulin resistance across different mouse strains and diets. Stöckli J, Fisher-Wellman KH, Chaudhuri R, Zeng XY, Fazakerley DJ, Meoli CC, Thomas KC, Hoffman NJ, Mangiafico SP, Xirouchaki CE, Yang CH, Ilkayeva O, Wong K, Cooney GJ, Andrikopoulos S, Muoio DM, James DE. J Biol Chem. 2017 Nov 24;292(47):19135-19145. doi: 10.1074/jbc.M117.818351. Epub 2017 Oct 5.

Multiplexed Temporal Quantification of the Exercise-regulated Plasma Peptidome. Parker BL, Burchfield JG, Clayton D, Geddes TA, Payne RJ, Kiens B, Wojtaszewski JFP, Richter EA, James DE. Mol Cell Proteomics. 2017 Dec;16(12):2055-2068. doi: 10.1074/mcp.RA117.000020. Epub 2017 Oct 5.

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodson MP, Ferguson C, Drowley L, Plowright AT, Needham EJ, Wang QD, Gregorevic P, Xin M, Thomas WG, Parton RG, Nielsen LK, Launikonis BS, James DE, Elliott DA, Porrello ER, Hudson JE. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8372-E8381. doi: 10.1073/pnas.1707316114. Epub 2017 Sep 15.

An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction. Norris DM, Yang P, Krycer JR, Fazakerley DJ, James DE, Burchfield JG. J Cell Sci. 2017 Aug 15;130(16):2757-2766. doi: 10.1242/jcs.205369. Epub 2017 Jun 29.

Bicarbonate alters cellular responses in respiration assays. Krycer JR, Fisher-Wellman KH, Fazakerley DJ, Muoio DM, James DE. Biochem Biophys Res Commun. 2017 Aug 5;489(4):399-403. doi: 10.1016/j.bbrc.2017.05.151. Epub 2017 May 27.

Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. Kleinert M, Parker BL, Fritzen AM, Knudsen JR, Jensen TE, Kjøbsted R, Sylow L, Ruegg M, James DE, Richter EA. J Physiol. 2017 Jul 15;595(14):4845-4855. doi: 10.1113/JP274203. Epub 2017 Jun 11.

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. Nelson ME, Lahiri S, Chow JD, Byrne FL, Hargett SR, Breen DS, Olzomer EM, Wu LE, Cooney GJ, Turner N, James DE, Slack-Davis JK, Lackner C, Caldwell SH, Hoehn KL. Nat Commun. 2017 Mar 14;8:14689. doi: 10.1038/ncomms14689.

The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. Krycer JR, Fazakerley DJ, Cater RJ, C Thomas K, Naghiloo S, Burchfield JG, Humphrey SJ, Vandenberg RJ, Ryan RM, James DE. FEBS Lett. 2017 Jan;591(2):322-330. doi: 10.1002/1873-3468.12549. Epub 2017 Jan 13.

2016

A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Li Z, Schulze RJ, Weller SG, Krueger EW, Schott MB, Zhang X, Casey CA, Liu J, Stöckli J, James DE, McNiven MA. Sci Adv. 2016 Dec 16;2(12):e1601470. doi: 10.1126/sciadv.1601470. eCollection 2016 Dec.

Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes. Minard AY, Wong MK, Chaudhuri R, Tan SX, Humphrey SJ, Parker BL, Yang JY, Laybutt DR, Cooney GJ, Coster AC, Stöckli J, James DE. J Biol Chem. 2016 Dec 2;291(49):25629-25640. Epub 2016 Oct 13.

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework. Solon-Biet SM, Cogger VC, Pulpitel T, Heblinski M, Wahl D, McMahon AC, Warren A, Durrant-Whyte J, Walters KA, Krycer JR, Ponton F, Gokarn R, Wali JA, Ruohonen K, Conigrave AD, James DE, Raubenheimer D, Morrison CD, Le Couteur DG, Simpson SJ. Cell Metab. 2016 Oct 11;24(4):555-565. doi: 10.1016/j.cmet.2016.09.001. Epub 2016 Sep 29.

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes. Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stöckli J, James DE. Cell Rep. 2016 Sep 27;17(1):29-36. doi: 10.1016/j.celrep.2016.08.086.

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP. Nat Commun. 2016 Sep 27;7:12862. doi: 10.1038/ncomms12862. Erratum in: Nat Commun. 2017 Aug 30;8:16125.

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Kleinert M, Parker BL, Chaudhuri R, Fazakerley DJ, Serup A, Thomas KC, Krycer JR, Sylow L, Fritzen AM, Hoffman NJ, Jeppesen J, Schjerling P, Ruegg MA, Kiens B, James DE, Richter EA. Mol Metab. 2016 Jun 22;5(8):646-55. doi: 10.1016/j.molmet.2016.06.007. eCollection 2016 Aug.

Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass. Davey JR, Watt KI, Parker BL, Chaudhuri R, Ryall JG, Cunningham L, Qian H, Sartorelli V, Sandri M, Chamberlain J, James DE, Gregorevic P. JCI Insight. 2016 Apr 21;1(5). pii: e85477.

KinasePA: Phosphoproteomics data annotation using hypothesis driven kinase perturbation analysis. Yang P, Patrick E, Humphrey SJ, Ghazanfar S, James DE, Jothi R, Yang JY. Proteomics. 2016 Jul;16(13):1868-71. doi: 10.1002/pmic.201600068. Epub 2016 May 27.

Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans. Tonks KT, Coster AC, Christopher MJ, Chaudhuri R, Xu A, Gagnon-Bartsch J, Chisholm DJ, James DE, Meikle PJ, Greenfield JR, Samocha-Bonet D. Obesity (Silver Spring). 2016 Apr;24(4):908-16. doi: 10.1002/oby.21448. Epub 2016 Feb 24.

 

 

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